Postdoctoral Fellow - Biocatalysis, Synthetic Chemistry and Technology Scale-Up

AstraZeneca seeks a postdoctoral fellow to develop biocatalytic chemistry and scalable reaction technologies for small-molecule synthesis. The one-year position, based in Gothenburg, focuses on hydrogen-driven enzymatic cascades for selective reductions and oxidations, advancing laboratory discoveries toward pharmaceutical manufacturing applications.

Responsibilities

• Design and execute enzymatic reaction cascades combining hydrogen, hydrogenases, and biocatalysts for selective transformations
• Optimize biocatalytic reactions from small-scale screening through preparative and larger-scale experiments
• Investigate reaction parameters including enzyme concentration, pH, temperature, solvent composition, and cofactor balance
• Characterize substrates, intermediates, and products using appropriate analytical methods
• Collaborate with AstraZeneca scientists, academic partners, and external technology providers to deliver scalable solutions

Requirements

• PhD in biocatalysis, synthetic organic chemistry, enzyme engineering, or related discipline
• Practical experience designing and executing independent research projects
• Strong understanding of organic chemistry and/or enzymatic catalysis principles
• Experience in experimental planning, reaction optimization, and scientific problem-solving
• Track record of research productivity demonstrated through publications or presentations
• Proficiency in analytical characterization techniques such as LC-MS, GC-MS, and NMR

Compensation: Competitive Salary & Benefits Package